Breakthrough Research Into the Benefits of CBD

Breakthrough research surrounding CBD

Breakthrough research surrounding CBD is making a real difference in the lives of people suffering from anxiety and depression. It also helps prevent viral replication in live animals, is a potential anti-cancer agent, and reduces cravings and anxiety. While these results are still preliminary, these findings are encouraging. Eventually, CBD may make its way onto the market as a commercial drug.

Cannabidiol prevents viral replication in live animals

CBD has been shown to inhibit viral replication by inhibiting the virus’s ability to replicate in the host cell. The compound works by inhibiting the viral replication process through innate immune responses and ER stress. The study was supported by grants from the National Institutes of Health, including R01 GM121735 and R01 CA184494. The study also received support from the Helmsley Charitable Trust and the Harry B. and Leona M. Helmsley Charitable Foundation.

The researchers exposed human lung cells to SARS-CoV-2 to see if CBD prevented the virus from replicating. CBD did not affect the SARS-CoV-2 virus’s ability to enter the cells, but it did inhibit the virus’s ability to replicate early in the infection cycle. CBD’s antiviral effects appeared as early as six hours after virus infection.

CBD was also shown to prevent viral replication in mice. CBD significantly reduced the viral load in the respiratory and nasal turbinates when injected into the animals. Further, both low and high doses of the compound inhibited viral replication, without causing clinical disease or weight loss. This suggests that CBD may act as an antiviral in early stages of SARS-CoV-2 infection.

Epidiolex is ready for commercial sale

After extensive clinical trials, Epidiolex is now available for sale as an over-the-counter (OTC) medication. This new drug has been approved by the FDA and was developed after breakthrough research on CBD. However, it is important to follow safety guidelines and precautions while taking this new medication. This will help prevent accidental drug exposure and environmental damage.

Epidiolex is the first medication derived from the cannabis plant that has been approved by the FDA for medical purposes. It contains both CBD and THC, but is extracted from cannabis specifically cultivated for medical use. The medicine is available in capsule form, and contains sesame oil, a flavoring agent, and a sweetener.

It is important to note that Epidiolex may interact with other medications. It may reduce the effectiveness of these medications or cause more side effects. Patients should always discuss the potential drug interactions with their healthcare providers before taking Epidiolex. The drug may also need prior authorization from insurance companies. To receive this authorization, your physician must first request the medication from the insurance company. The insurance company will review this request and make a decision about whether or not Epidiolex is covered by your insurance.

CBD is a potential anti-cancer agent

In recent studies, researchers have found that cannabinoids can inhibit the progression of prostate cancer by inhibiting Id-1 expression and fibroblast activation. Further, cannabinoids inhibit the expression of the apoptotic gene P53 and can enhance the immune checkpoint blockade of pancreatic cancer cells.

In addition, CBD inhibits PPARg, a transcription factor that regulates the progression of cancer. This effect is believed to be related to its antimetastatic action. CBD also inhibits the production of the inflammatory protein IL-1. CBD is also effective at reducing the expression of the enzyme mTOR.

In a study that involved breast cancer patients in the UK, researchers found that CBD reduced the viability of tumor cells in 92% of cases. These women were given CBD as the only treatment for their disease and seven patients achieved tumor-free status. Moreover, CBD reduced the number of tumors in 28 of 39 patients with advanced cancer. Researchers administered CBD to patients on a three-day-on, three-day-off basis, increasing the dosage to 30 mg daily if the tumor mass increased.

Another study concluded that CBD has anti-inflammatory and anti-invasive effects on lung cancer. In a 2010 study, researchers observed a 63% reduction in invasion of A549 cells, which are a model for human lung cancer. CBD also reduced the size of the tumor and prevented the development of lung metastases. Another study conducted in 2013 also found that CBD reduced the number of cancer cells in two types of lung cancer.

It reduces cravings and anxiety

In studies involving patients in the treatment of addiction, CBD has shown promise in reducing cravings and anxiety. The substance also lowers the body’s levels of stress hormones and heart rate. It also appears to lessen cravings in those who have recently abstained from substance use. Researchers believe that CBD could be a valuable adjunct to existing treatments for drug addiction. However, they note that more work needs to be done to ensure that it is a safe, effective option for those who are suffering from the consequences of addiction.

In the present study, CBD was associated with reduced cue-induced craving and anxiety in participants with opioid and alcohol dependence. These findings may be important in developing medications that can reduce the stigma associated with OUD. Further research will provide a better understanding of how CBD affects the brain’s physiological status.

A new study from Mount Sinai Beth Israel Hospital found that CBD reduces cravings and anxiety in patients with heroin use disorder. The study tested two different dosages of CBD in three groups. One group received placebo, while the other received either 400 or 800 milligrams of CBD. The participants reported decreased anxiety and craving after receiving the drug, and lowered levels of the stress hormone cortisol in saliva. These effects lasted for a week after the final dose was given.

Athletes Use CBD For Pain Relief

CBD for pain reliefAthletes are using CBD for pain relief for a number of reasons. This compound affects the serotonin receptors in the brain and reduces pain by inhibiting the release of glutamate. These processes occur because CBD affects serotonin receptors and immune cells. It is therefore believed to be a great alternative for athletes who experience pain during their sports.

Cannabidiol inhibits glutamate release

CBD exerts analgesic properties in several neuropathic pain models. For example, CBD-containing gelatine inhibited mechanical allodynia and reversed conditional place preference induced by peripheral nerve block in a mouse model of chronic neuropathic pain. In contrast, morphine and D9-THC induced tolerance after only one week of treatment, and neither CBD nor morphine caused a significant decrease in hyperalgesia. In addition, CBD suppressed pain induced by ligation of the L5 spinal nerve in rats.

CBD also inhibits the release of glutamate and other inflammatory agents. As a result, it is an excellent pain-relief agent for neuropathic pain. Combined with magnesium glycinate, CBD has been proven to be effective at dulling neuropathic pain sensations.

It affects serotonin receptors

Researchers have recently discovered that CBD can affect serotonin receptors, which are responsible for a wide range of effects, including pain relief. The study showed that CBD was able to decrease the sensitivity of 5-HT1A receptors in mice. This decreased sensitivity could be the result of a decrease in the availability of serotonin in the central nervous system.

The effects of CBD on serotonin receptors are mediated by interactions with TRPV1 channels and 5-HT1A receptors. The results indicated that CBD decreased the rate of firing by 5-HT neurons in the dorsal raphe nucleus, and that it prevented SNI-induced reductions in firing activity.

It reduces pain through serotonin receptors

In a study conducted in rats, CBD increased the activity of 5-HT1A receptors, which are involved in pain signaling. CBD treatment reduced the latency to feed and reduced anxiety-like behavior in SNI rats. Furthermore, CBD treatment restored normal activity of 5-HT1A receptors, preventing aberrations in 5-HT neurotransmission under neuropathic pain conditions.

The findings suggest that CBD may reduce pain through serotonin receptors. This receptor system controls the expression of serotonin and dopamine. When activated, serotonin and dopamine trigger a response that relieves pain. As a result, CBD is a promising candidate for chronic pain treatment. Moreover, its low potential for abuse and diversion makes it a highly attractive drug for medical use.

The ECS regulates body processes, such as mood, sleep, immune system function, and metabolism. It is made up of cannabinoids produced by the body, which act on specific receptors throughout the nervous system. CBD, like other cannabinoids, binds to these receptors to modify pain perception.

It relieves pain through immune cells

In studies of CBD’s impact on immune cells, it appears that it has an anti-inflammatory effect. This has been demonstrated through its ability to suppress inflammation, cytokines, and kinase cascades. Additionally, it inhibits the activity of several transcription factors, such as NF-kB and AP-1.

CBD works on the endocannabinoid system, which regulates the release of different chemicals in the brain. Endocannabinoids are naturally produced by the human body and act on nerve junctions and receptors. When they are functioning properly, they regulate pain signals and regulate immune cells and inflammation. When this system is obstructed, the body experiences abnormal pain sensitivity and inflammation. Fortunately, CBD inhibits pain signals by activating CB1 and CB2 receptors in the brain.

Studies have shown that CBD may reduce pain caused by arthritis. The compound has been shown to decrease inflammation in arthritis rats and also reduce the sensitivity of the primary pain receptors in the joints. In addition, CBD also decreases inflammatory molecules in the joint space and prevents joint cartilage breakdown.

It may relieve rheumatic diseases like fibromyalgia

Cannabis and CBD have several therapeutic properties, and research has suggested that CBD may help relieve rheumatic diseases like autoimmune diseases and fibromyalgia. Like other treatments for rheumatic diseases, cannabis should be taken in a controlled dosage. To prevent side effects, doctors usually begin with low dosages and gradually increase the dose. Patients should be in constant communication with their doctor regarding the dose. The aim is to determine the lowest effective dose that produces maximum effect with the fewest side effects. This process is known as identifying the therapeutic window.

Fibromyalgia is a chronic illness that inhibits pain processing in the spinal cord and brain. The pain sensation is so intense that it can be associated with other conditions such as anxiety and depression. Because it is difficult to diagnose, doctors typically rely on a “process of elimination” approach, using multiple surveys and tests. This can include blood tests, ultrasounds, and x-rays. Ultimately, they will want to rule out other health conditions before prescribing medication. Patients with fibromyalgia may find some relief from symptoms with proper self-care.

Volcano Hybrid vaporizer review

The Volcano Hybrid Vaporizer Review: Is It the Best on the Market?

If you’re in the market for a high-quality vaporizer, then you should definitely consider the Volcano Hybrid. This device is made by Storz and Bickel, the company that makes the famous Volcano, Mighty and Crafty vaporizers. So, what makes the Hybrid so unique? Let’s take a closer look!

If you’re a vaping fan, finding a vaporizer that offers consistent convection quality vapor is one of the most important things. It is essential if you plan on using it in group scenarios. The Volcano Hybrid offers just that! Not only does it offer excellent convection quality vapor, but it also allows you to use either balloons or a whip, making it perfect for any situation.

Another great thing about the Volcano Hybrid is that it’s straightforward to use. Even if you’re new to vaping, you’ll be able to figure out how to use this device in no time. And, if you ever have any questions, the instruction manual.

I first heard about Volcano Hybrid when looking for a new vaporizer. I had seen the Volcano and Mighty models before but wasn’t familiar with the new Hybrid version. After researching, I decided it would be the perfect vaporizer for me. Not only does it offer excellent convection quality vapor, but it also allows you to use either balloons or a whip, making it perfect for any situation.

I decided to try the Volcano Hybrid because I was looking for a new vaporizer offering consistent convection quality vapor. I also wanted a device that would be easy to use and clean.

What is the Volcano Hybrid?

The Volcano Hybrid is a high-quality vaporizer made by Storz & Bickel. It is an updated version of the Volcano Classic and offers many improvements and new features. One of the most notable changes is the inclusion of a new whip accessory, which allows you to enjoy your vapor in various ways.

The Volcano Hybrid also features a new and improved heating system, which offers up to 230 watts of power. This means that your vapor will be hotter and more consistent. Additionally, the Volcano Hybrid is compatible with balloons and whips, so you can enjoy your vapor whichever way you prefer.

The Volcano Hybrid is perfect if you want a high-quality vaporizer that offers consistent convection quality vapor. It’s easy to use, clean, and compatible with balloons and whips. Order your Volcano Hybrid today!

Volcano Hybrid is a high-quality vaporizer made by Storz & Bickel. Storz & Bickel is a German company making high-quality vaporizers for over 20 years. The Volcano was their first product, and it quickly became one of the most popular vaporizers on the market. The Volcano Hybrid is an updated version of the Volcano Classic and offers many improvements and new features. One of the most notable changes is the inclusion of a new whip accessory, which allows you to enjoy your vapor in various ways.

Volcano Hybrid uses pure convection vaporization to get the most out of your vaporized herbs. It means hot air is passed over your herbs or concentrates rather than directly through them. It results in more even vaporization, ensuring that all the active ingredients in your herbs are vaporized.

Volcano Hybrid Vaporizer Pricing

The Volcano Hybrid is priced at $599.00. This may seem like a lot, but it’s reasonable when you compare it to other high-end vaporizers on the market. The Volcano Hybrid offers many features and benefits unavailable on other devices, making it well worth the price tag. The Volcano Hybrid is the perfect device if you’re looking for a high-quality vaporizer that offers consistent convection quality vapor. Order your Volcano Hybrid today!

Volcano Hybrid Features

Here is what we liked the most with this product:

Amazing Vapor Quality

The Volcano Hybrid uses pure convection vaporization to get the most out of your vaporized herbs. It means that hot air is passed over your herbs rather than directly through them, resulting in more even vaporization, ensuring that all the active ingredients in your herbs are vaporized.

Hybrid Filling Chamber

The Volcano Hybrid uses a hybrid filling chamber, which can be used with dry herbs and concentrates. It makes it one of the most versatile vaporizers on the market, allowing you to enjoy your vapor in various ways.

Precision Temperature Control

Volcano Hybrid offers precision temperature control, so you can always vaporize your herbs at the perfect temperature. It ensures that you’re getting the most out of your vapor and allows you to customize your experience to suit your needs.

Hybrid Whip System

The Volcano Hybrid uses a hybrid whip system, which can be used with balloons and whips. This makes it one of the most versatile vaporizers on the market, allowing you to enjoy your vapor whichever way you prefer. The Volcano Hybrid is also compatible with various accessories, so you can customize your experience to suit your needs.

Medical Certification

The Volcano Hybrid has a medical certification, which means that it’s been tested and approved by medical professionals. It makes it one of the safest vaporizers on the market and ensures you’re getting a high-quality product. A five-year warranty backs the Volcano Hybrid, so you can be sure you’re getting a product that will last.

The Volcano Hybrid is a medical device in both the US and Israel!

Bluetooth and App Info

The Volcano Hybrid offers Bluetooth and App info. This allows you to keep track of your vaporizer’s performance and ensure that it is working correctly. It also allows you to customize your vaporizing experience to suit your needs.

First Impressions

The Volcano Hybrid has a modern look with a nice-looking screen and temperature buttons. It’s sleek and stylish, and it looks great on any countertop. The Volcano Hybrid is also very easy to use, and the instructions are clear and concise. I was able to set up my vaporizer quickly and easily!

Volcano Hybrid is a quality-made product that I would recommend to anyone. It has a modern look and sleek design and is very easy to use. The Volcano Hybrid offers precision temperature control, so you can always vaporize your herbs at the perfect temperature.

The Volcano Hybrid’s hybrid whip system is one of the things I like most about it, and I can use it with both balloons and whips, which makes it very versatile. I also like how easy it is to use – the instructions are clear and concise, and I was able to set up my vaporizer quickly and easily.

Thoughts on Using the Volcano Hybrid

I’ve been using the Volcano Hybrid for about 6 months now, and I’m very impressed. The vapor quality is fantastic, and I love how precise the temperature control is. I’ve also really appreciated being able to use it with both dry herbs and concentrates. Overall, I’m thrilled with my purchase and recommend it to anyone looking for a high-quality vaporizer.

Reliable vaporizer

The Volcano Hybrid is a reliable vaporizer because a five-year warranty backs it. This means you can be sure you’re getting a product that will last. The Volcano Hybrid is also certified by medical professionals, so you can be confident that you’re getting a high-quality product.

Consistent quality convection vapor

The Volcano Hybrid offers consistent quality convection vapor because it has precision temperature control. This means you can always vaporize your herbs at the perfect temperature, ensuring you get the most out of your vapor.

Very easy to use and clean

The Volcano Hybrid is very easy to use because the instructions are clear and concise. I could set up my vaporizer quickly and easily, and I was vaping within minutes. The Volcano Hybrid is also very easy to clean, which is a big plus. Overall, I’m delighted with my purchase and recommend it to anyone!

Extremely easy to pass the balloon around, and the whip system is perfect in group scenarios.

The Volcano Hybrid has a hybrid whip system that is very easy to use, and I can use it with both balloons and whips, which makes it very versatile in any setup. It makes it extremely easy to pass the balloon around, and the whip system is perfect in group scenarios.

My Results/Verdict

The Volcano Hybrid surpassed our expectations for the Volcano Classic, incorporating many modifications and improvements we had suggested. The vapor quality is even better, and the app’s functionality allows you to play with various settings and even activate it remotely. Put a balloon on the device and go to the bathroom while telling it to heat up. When you get back, your balloon will be ready.

The Volcano Hybrid is as good as it gets for a regular user who wants the finest of the best and has enough money to burn. The huge heater with up to 230 watts of output is incredibly robust, and Storz & Bickel’s legendary craftsmanship closes the deal. There are no concerns or problems; set it and forget it.

The Volcano Classic is a great model, but if you already own one, the most significant upgrade might not be worth it. Sure, the new models are slightly better in performance and versatility overall- but if you’re happy with your current device, switching might not give you too much of an advantage.

We were blown away by the quality of this new version and liked the new whip accessory!

Find the best price for the Volcano Hybrid by visiting this page!


– precision temperature control

– easy to use

– easy to clean

– backed by a five-year warranty

– certified by medical professionals

– consistent quality convection vapor


– price tag may be too high for some people’s budgets.

– Volcano Classic may be just as good for some people.

– not much of an upgrade from the Volcano Classic for some people.


Is the Volcano Hybrid worth the price tag?

The Volcano Hybrid is a high-quality product backed by a five-year warranty. The Volcano Hybrid is an excellent option if you are looking for a reliable vaporizer.

How does the Volcano Hybrid compare to the Volcano Classic?

The Volcano Hybrid has a few improvements over the Volcano Classic, including precision temperature control and a hybrid whip system. The Volcano Classic is still a great option, but the Volcano Hybrid is the better choice if you are looking for the best of the best.

What are some of the pros and cons of the Volcano Hybrid?

Some pros of the Volcano Hybrid include the precision temperature control, easy-to-use interface, and easy-to-clean design. Some cons of the Volcano Hybrid include the high price tag and that it may not be much of an upgrade from the Volcano Classic for some people.

Where can I find the best price for the Volcano Hybrid?

By following the links provided in this article


– Volcano Hybrid review

– Volcano Hybrid

– Volcano hybrid whip system

– Volcano hybrid balloon system

– Volcano hybrid concentrates chamber

– Volcano hybrid features

CBD oils

Buying CBD in France: the guide to finding your way around

If you’re new to the world of CBD, making your first purchase can seem daunting. There are so many brands and products on the market today that it can be difficult to find the right product for your needs.

Before buying CBD, and to make sure it is effective, there are many factors to consider such as the type of product, the percentage of CBD, the reliability of the seller, the source of the CBD and, above all, your need.

At Dhpregie we believe that there is a CBD product for every individual. Our guide will help you find yours and advise your loved ones if necessary.

Why buy CBD when in Europe?

CBD is one of 120+ compounds, or cannabinoids, found in the hemp plant (cannabis sativa L). It is the second most abundant cannabinoid after tetrahydrocannabinol (THC). However, unlike THC, CBD is not a psychotropic drug. It is thanks to the isolation of the CBD molecule that it is possible to enjoy the benefits of the plant while avoiding its narcotic effects. It is neither addictive, nor toxic and does not “get high”.

Cannabinoids act in various ways on the body’s endocannabinoid system. This system plays a crucial role in maintaining the various balances of the body. On the scale of the human body, it is for example the management of weight, body temperature, blood sugar, heart rate, digestive system … etc..

In this sense, CBD would have the following properties:

  • anti-inflammatory
  • anticonvulsant
  • analgesic (pain)
  • anxiolytic (anti-anxiety)
  • sedative
  • antipsychotic

American scientific research is advancing rapidly and now proves that CBD has beneficial effects on health. In addition, the French government and the Ministry of Health are committed to starting a medical cannabis trial program. On the other hand, it is currently forbidden to promote the potential beneficial effects of CBD until the information has been officially ruled by the State.

There appear to be very few adverse side effects, and most people tolerate it well. CBD is not abused or addictive, as long as people don’t mix it with other potentially toxic substances.

CBD is increasingly used around the world to help relieve stress and anxiety, manage pain and induce a sense of well-being, among other things.

Is buying CBD legal in France?


Buying CBD in France is legal, but the legislation is still vague. It authorizes the purchase of CBD provided that the CBD product is derived from a hemp plant with a THC content of less than 0.2%. Be careful to select a reliable brand working with producers who implement controls.

What types of CBD products to buy?

Choosing the right product is important because each ingestion method has a different level of effectiveness, therapeutic properties, onset and duration. Below are the most popular product categories currently available.

oil made of cannabidiol sold in France

CBD oils

CBD oils are by far the most popular products available today. Oils trump all other types of CBD products when it comes to dosing accuracy. In fact, all oils come with a precise dropper that makes it easy to increase or decrease doses.

The oil is the fastest method of absorption. It is absorbed sublingually (under the tongue), which means it works faster than most other forms of CBD products.

When starting out, buying oil may be the right method to be able to go gradually and know your ideal dosage. Visit this partner website to find the best CBD oils in France

Choosing the right spectrum

One of the first things you’ll see about CBD oils is their “spectrum.”

The spectrum actually represents the concentration of cannabinoids present in the extract.

Full spectrum CBD oils contain a wide variety of cannabinoids and terpenes from the original hemp plant. These products are known to offer maximum therapeutic benefits because they contain the widest variety of compounds available and take advantage of the entourage effect: that is, the potency of all the components added together. Moreover, they also contain a tiny dose of THC, but this one does not have psychotropic effects and is normally undetectable since it is lower than 0,2%.

Oils with broad spectrum

The CBD isolate oils (isolate) contain only CBD without THC and other cannabinoids. These are not recommended because they do not take advantage of the surrounding effect of the hemp plant. On the other hand, they should be preferred by people who are sensitive or even intolerant to THC.

To summarize: if you wish to benefit from the therapeutic effects of CBD you must privilege the purchase of oil with broad spectrum or complete for their strong concentrations in cannabinoids.

CBD flowers

Flowers are one of the purest and most natural forms of CBD consumption. They will be ideal if you are already a smoker and you are nostalgic of the gesture or the effect of cannabis for example. CBD can be a good way to reduce its consumption.

Be careful though, CBD does not give you the high of cannabis, it is a different effect and the collateral effects of the substances that will accompany your intake such as tobacco for example can be bad.

Like oils, when you inhale CBD and other cannabis compounds, the effect comes on quickly, but it will last less time.

Our plants, from seeds registered in the EU catalog of seeds and varieties, produce CBD flowers that do not contain THC (<0.2%) and are thus authorized in France and in Europe.…

main benefits of CBD

The best reasons to try CBD

These days, you are probably noticing more and more people around you consuming CBD and you are still on the fence? The “miracle product” claims are leaving you skeptical?

We must admit that all the virtues that we lend it may seem “too good to be true”, but the potential of CBD is confirmed more and more over the years, whether in terms of consumer feedback, or with scientific research. If you are still not convinced, here are some reasons that should change your mind!

It soothes everyday ailments in a natural way

First of all, you should know that CBD is a totally legal molecule. Unlike its cousin THC, it does not induce any high or any other side effect. You do not have any risk of addiction to try CBD, because it is directly extracted from the hemp plant. Completely natural, it relieves you and will eventually avoid you to use a heavier drug treatment!

CBD improves recovery after exercise

Contrary to popular belief, CBD is not reserved for people subject to stress or physical problems! Indeed, more and more athletes are trying it, because the use of CBD-based oils or balms allows them to recover better, by relaxing their muscles after an effort!

It helps taking care of your skin

Combined with hemp oil, CBD is particularly useful against skin problems. Thanks to its moisturizing, antiseptic, and anti-inflammatory properties, it helps regulate sebum production. You should therefore try it if you suffer from skin problems such as eczema, hives or psoriasis… It is even effective in relieving your sunburn!

CBD reduces stress

Known for its relaxing effects, CBD undoubtedly helps you relax, but can also act as a mild antidepressant. So you can try CBD in times of increased stress, to help reduce your anxiety disorders: a few drops of CBD oil or a hemp tea will do the trick!

It provides a better sleep

The human body reacts to CBD because it interacts with the receptors of the endocannabinoid system, which is directly linked to the nervous and immune systems. This system also plays a role in the body’s homeostasis, which helps regulate our sleep cycles: a better regulated homeostasis cycle makes it easier to fall asleep, while enjoying a much better quality of sleep.

It relieves chronic pain

Another reason to try CBD is its proven anti-inflammatory effect. According to some studies, this product could soothe certain joint pains such as osteoarthritis, but also back pain and certain neurological ailments! Why deprive yourself of it?

cbd and opioid addiction

CBD drug to treat opioid addiction

The Ananda company has just started clinical trials to use Nantheia ATL5. This drug, which contains a high dosage of CBD, could perhaps be used to help people addicted to opioids!

Coming from Colorado, this biotech has just received the authorization of the FDA (Food and Drug Administration), which represents the high authority of health in America. The clinical trial will be supervised by UCLA (University of California).

A CBD drug acting as a substitute for opioids

Concretely, the Nantheia ATL5 is a capsule containing 100 mg of CBD. If the studies conducted on it are conclusive, this drug could potentially replace opioids in the treatment of patients suffering from chronic pain.

According to the results of this study, this CBD drug could be on the same rank as Epidiolex. Note that today, GW Pharma’s liquid solution is the only CBD-based medication authorized in both the United States and the European Union!

Sohail Zaidi, CEO of Ananda, is delighted with this news, and explains: “The authorization to conduct a clinical trial further strengthens our goal of developing CBD as a therapy for several diseases”.

For Edith London, the psychiatrist leading the trials, the approval of this work is a critical step in finding solutions to the opioid-induced crisis.

The ravages of opioids

The current opioid crisis in the U.S. is unprecedented in its severity. These drugs, such as Fentanyl or Oxycodone, produce effects that are very similar to those of opium. They are therefore useful when it comes to alleviating chronic pain, but the downside is very high, as these drugs are also very addictive, and harmful to health. Their use in high doses can be fatal, which is why every year there are about 50,000 deaths related to their use in the United States! It is in this context that President Donal Trump decreed that there was a public health emergency during 2017.

It is thus without real surprise that the FDA places a lot of hopes in the Nantheia ATL5. Highly dosed in CBD, this drug candidate could be used to relieve chronic pain. Indeed, its molecule has anti-inflammatory virtues that are no longer to prove, and unlike opioids, it does not cause any addictive effect, and is not psychoactive!

The effects of this CBD drug would be very similar to those of Fentanyl or Oxycodone, but without their drawbacks! CBD in too high a dose is not ideal for liver health, but this is in no way comparable to the devastating effects of opioids.

The clinical trial will be fully funded by NIDA (National Institute on Drug Abuse), which is also very excited about this promising project!


CBD and sleep : what do we know

Nowadays, sleep is a precious commodity in everyone’s life. The relentless acceleration of our societies and lifestyles have made it something sacred. But despite this, many people suffer from problems or disorders related to their sleep. If we add to this the stress due to work or our private life, in addition to our addiction to screens, it is difficult for some people to benefit from the 7 or 8 hours of sleep necessary for the proper functioning and recovery of our body. And as is often the case with everyday ailments, CBD can be a “miracle” solution. Indeed, today, cannabidiol represents the most natural and healthy alternative to promote a good sleep. So how does it act on sleep? What are its benefits? Here is our anwers to these questions.

The positive impact of CBD on our sleep

First of all, it is good to know that, unlike sleeping pills or other drugs that promise a better sleep, CBD is 100% natural and does not cause any addiction or side effects. Promoted by the natural presence of the Endocannabinoid System. The latter has the function of linking our organs through the secretion and circulation of various hormones, such as melatonin. A network of receptors with which CBD matches perfectly. Thus, after consumption, it interacts directly with the CB1 and CB2 receptors, which makes it capable of regulating our fatigue, our concentration or many of our emotions, such as stress and anxiety for example. Therefore, and concerning sleep, cannabidiol acts in a direct way on what is called the “sleep-wake” system, in charge of regulating our rate of fatigue and our capacity of recovery. If you add to this its therapeutic, anti-inflammatory and anti-pain properties, you will understand why it can be an excellent ally against sleep disorders and problems.

The benefits of CBD on our sleep

Consuming CBD before slipping into bed will therefore promote better relaxation, whether physical or psychological. What to approach the sleep with the mind lighter and freer than usual, our brain tends to be quite agitated when we go to sleep. And in addition to improving the quality of your night, cannabidiol will help you go to bed faster and therefore sleep longer. The different stages of sleep will be reached in a smoother and more cushioned way, which will generate a deep as well as light sleep, thus promoting the recovery of the individual. Unlike sleeping pills or other artificial pharmaceutical drugs, which tend to knock out rather than soothe, causing a reaction in the brain, which could lead to a feeling of addiction to the substance. What there is no risk of happening with CBD.

How to consume CBD to promote sleep?

CBD offers its followers the chance to consume it in multiple ways, but also to accentuate certain therapeutic effects. In addition to that, cannabidïol has the advantage of presenting no risk of overdose. Its effects are absolutely not psychotropic and dangerous for health, unlike its cousin THC. It is thus possible to consume it under bigger dose when one wants to use it for its sleep. Be careful not to consider this cannabinoid as a medicine in its own right, but also to consult your doctor before any consumption. The latter will help you to better target your needs and to optimally manage your CBD experience.

The infusion remains at the moment, the most practical way to make benefit to the whole of its body, principles and virtues of the CBD. The fact that one drinks it will support a better dissipation in the body, and this, always thanks to the SEC. The vaporization of resin or flowers remains also an excellent way to impact positively its sleep thanks to the cannabidiol. However, the duration of the effects will be less than the one generated by the ingestion of an herbal tea. As for CBD oils and cosmetics, their more local application will be less effective on our sleep-wake system. They will be more likely to treat other ailments such as muscle pain or chronic pain for example.


cannamoms tendance

“Cannamoms”: mothers who swear by cannabis

More and more women are using microdoses of cannabis to relax. They believe it helps them to be more available mothers to their children, reports the BBC website.

What if using cannabis helps you be a better parent? According to the BBC, more and more women are defining themselves as “cannamoms” and defending this point of view.

An American journalist started the trend

This is the case of Danielle Simone Brand, an American journalist who got into it in 2016, when California legalized consumption for adults. This mother of two children aged 8 and 11 even made a book about it, published in December 2020, Weed Mom: The Canna-Curious Woman’s Guide to Healthier Relaxation, Happier Parenting, and Chilling TF Out (“Maman Beuh: le guide de la femme canna-curieuse pour une relaxation plus saine, une parentalité plus heureuse et pour une p* de détente”).

In it, Brand explains that cannabis helps her not to be overwhelmed by the mental load of daily tasks and to have more patience and availability for her children.

This phenomenon is actually not new, but it seems to be growing judging by the number of “cannamoms” groups on social networks. Heather McIlvaine-Newsad, a professor of anthropology at Western Illinois University, is part of an interdisciplinary research project on cannabis and culture. She became aware in 2018 of Facebook groups about cannabis and parenting. Some had existed for many years and there are nearly 30 in all, each with thousands of members.

Latrese Thomas, a 40-year-old African-American mother of three, told the BBC that she uses cannabis “the same way others drink wine.” She added that, in the context of racial tensions particularly affecting the black community, cannabis “helped her control [her] anxiety as a mom – and not just as a black woman, but as a mom of black kids.” Many women also explain that their use has helped them cope with the stress of Covid and health measures.

The key: always microdose

The key, they all say, is to microdose. The BBC insists that there are no conclusive scientific studies on the effects of microdosing in the medium or long term, but it is certain that it can affect concentration and disrupt certain motor functions.

Precisely, all the consumers interviewed by the BBC mention the frowns they observe when they talk about their lifestyle. Latrese Thomas is aware of this and is careful who she talks to about it, especially since she is black, she points out. Heather McIlvaine-Newsad sums it up this way:

“It’s socially acceptable for a mother to say ‘Mommy needs a little glass of wine,’ but it’s still not acceptable to say ‘Mommy needs a microdose of cannabis.'”

Nevertheless, mentalities seem to be changing, especially with the arrival of a generation that has seen its parents but also its grandparents take cannabis. The “cannamoms” would thus have beautiful days before them.…

malta legalize cannabis

Malta to legalize cannabis for personal use in a European first

The move by the EU’s smallest member state is expected to be followed by reform in the rest of the continent in 2022

Malta will this week become the first European country to legalize the cultivation and possession of cannabis for personal use, propelling Luxembourg into the post as the continent undergoes a wave of changes in its drug laws.

A limited amount

Possession of up to seven grams of the drug will be legal for people aged 18 and over, and it will be permissible to grow up to four cannabis plants at home, with up to 50g of the dried product available for storage.

A vote in favor of the legislation in Malta’s parliament on Tuesday will be followed by the president signing the law into law by the weekend, Owen Bonnici, the minister responsible, told the Guardian.

The decision in Malta, the EU’s smallest member state, is likely to be followed by a Europe-wide reform in 2022. Germany recently announced the creation of a legally regulated market, following announcements by the Swiss, Luxembourg and Dutch governments. A referendum in Italy is planned, while Canada, Mexico and 18 U.S. states have already passed similar legislation.

Boris Johnson’s British government, on the other hand, has been accused of adopting a Richard Nixon-style “war on drugs” approach after maintaining its hard-line approach to cannabis use and making criminal sanctions for class A drug users a central plank of its recently released 10-year strategy.

Promoting recreational drugs

Bonnici said his government did not want to encourage the use of recreational drugs, but that there was no evidence to support the argument that cannabis use was in itself a gateway to harder substances.

He said, “There is a groundswell of understanding now that the hard-line approach against cannabis users was disproportionate, unfair, and gave a lot of pain to people who lead exemplary lives. But the fact that they use cannabis as a personal matter puts them in the jaws of crime.

He added: “I am very happy that Malta is the first country to put words in a law in a comprehensive way with a regulatory authority.

The change in approach by a number of European governments follows a UN decision last December to remove cannabis from a list of drugs designated as potentially addictive and dangerous, with little or no therapeutic use.

The Maltese approach aims to avoid criminalizing all cannabis use while regulating to ensure risk reduction, Bonnici said.

Possession of up to 28 grams will result in a fine of €50 to €100 but no criminal record. Those under 18 who are found in possession will go before a justice commission for recommendation of a care plan rather than being arrested. Those who consume cannabis in front of a child will face fines of between €300 and €500.

No private cultivation allowed

Beyond allowing people to grow plants at home, albeit out of public view, it will be legal for non-profit cannabis clubs to grow the drug for distribution to their members, similar to the organizations tolerated in Spain and the Netherlands.

Club membership will be limited to 500 people and only up to 7 grams per day can be distributed to each person, with a maximum of 50 grams per month. The organizations, which cannot be located within 250 meters of a school, club or youth center, can also distribute up to 20 cannabis seeds to each member each month.

Bonnici said his government has had a long debate about whether to put controls on the strength of cannabis that can be grown and used, measured by the level of the key psychoactive, or mood-altering, ingredient delta-9-tetrahydrocannabinol (TCH).

He said, “We had a huge discussion internally about this. And we concluded that if a limit [can be set] on the strength of cannabis, the THC levels, you will create a new market for the black market. What we need to do is educate people and inform them day by day.”

The Netherlands is perhaps the European country most associated with a relaxed attitude toward cannabis use. However, possession and trade are technically illegal there. Instead, the government has a gedoogbeleid, a “tolerance policy,” under which use is widely accepted within limits. A trial is planned in which production of the drug will be regulated.


US teens are not using more cannabis as states legalize

US teens are not using more cannabis as states legalize

Cannabis use among American youth fell in 2020 as a result of the coronavirus pandemic and the increase in the number of states adopting legalization, according to a newly released U.S. federal survey.

As a result, past-year cannabis use among 12- to 17-year-olds dropped from 13.2 percent to 10.1 percent between 2019 and 2020, according to the survey conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA). Among 18- to 25-year-olds, over-the-year use also dropped from 35.4 percent to 34.5 percent from the previous year.

Use among adults 26 and older, however, has trended upward in recent years.

For this survey, researchers noted that the methodology was modified due to the COVID-19 pandemic. For example, interviews were conducted virtually, rather than in person, for safety reasons. Because of this change, “caution should be used when comparing estimates,” they said.

Accumulating data

Numerous studies were now that cannabis legalization does not lead to an increase in youth use.

For example, a study published by the Journal of the American Medical Association in September found that rates of cannabis use among teens do not increase after legalizations for medical or recreational purposes.

National Institute on Drug Abuse (NIDA) Director Nora Volkow also admitted in a recent interview that legalization has not led to an increase in youth use, despite her earlier fears.

In a separate, earlier analysis, the Centers for Disease Control and Prevention found that marijuana use among high school students declined during the peak years of state legalization of recreational cannabis.

According to the survey, there was “no change” in the rate of current cannabis use among high school students between 2009 and 2019. However, when analyzed using a quadratic change model, lifetime marijuana use decreased during that time.

Another study released by Colorado officials last year found that youth cannabis use in the state “has not changed significantly since legalization” in 2012, although methods of use are diversifying.

In Canada, cannabis use among 15- to 17-year-olds has dropped 47% since legalization…